Methionine metabolic process

Across TCGA cell cohorts, RNA activity of the Methionine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLTF, CRELD2, and MMP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLTF grouped by Methionine metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HLTF →	-0.804	-0.777	.002	.005	3	4
LUNG_SCLC	CRELD2 →	+0.732	+0.848	.001	.004	3	4
OVARY	MMP2 →	-2.631	-0.966	.001	<.001	3	4
LUNG_NSCLC_LUAD	DEPDC4 →	-0.556	-0.698	<.001	.004	3	3
LUNG_NSCLC_LUAD	CEP63 →	-0.364	-0.712	.009	.007	2	4
CNS	KIAA0513 →	+0.768	+0.867	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLTF by Methionine metabolic process activity — OVARY

Explore this box plot interactively →