Methionine metabolic process

Across TCGA cell cohorts, RNA activity of the Methionine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT10C, SMS, and QTRT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Methionine metabolic process activity versus TRMT10C in KIDNEY (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TRMT10C →	+0.643	+0.183	.003	.002	3	5
BLOOD_Myeloma	SMS →	+1.360	+0.357	.001	<.001	3	5
LUNG_SCLC	QTRT2 →	+0.760	+0.335	<.001	.004	2	5
LARGE_INTESTINE	SLC25A32 →	+0.489	+0.154	.005	.005	3	4
OESOPHAGUS	RPL24 →	+1.140	+0.355	.002	.001	3	4
BLOOD_Leukemia	SLCO5A1 →	+0.661	+0.170	.006	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006555 vs TRMT10C — KIDNEY

Explore this scatter interactively →