L-leucine metabolic process

Across TCGA patient cohorts, RNA activity of the L-leucine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAT2, TGFB3, and P3H3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine metabolic process activity versus BCAT2 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCAT2 →	+0.411	+0.079	<.001	<.001	3	5
OV	TGFB3 →	+0.667	+0.047	<.001	.003	3	5
COAD	P3H3 →	+0.627	+0.057	<.001	<.001	3	5
COAD	P3H4 →	+0.971	+0.064	<.001	<.001	3	5
PDAC	PLXNA1 →	+0.370	+0.044	<.001	.003	3	5
BRCA	HTRA1 →	+0.823	+0.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006551 vs BCAT2 — GBM

Explore this scatter interactively →