L-leucine metabolic process

Across TCGA patient cohorts, RNA activity of the L-leucine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUB1B, PMP22, and GPC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine metabolic process activity versus BUB1B in COAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BUB1B →	-0.441	-0.139	.006	.001	3	6
LSCC	PMP22 →	+0.478	+0.086	<.001	<.001	3	6
GBM	GPC2 →	-0.777	-0.083	.004	.001	3	5
UCEC	CENPA →	-0.839	-0.084	.001	.007	3	5
UCEC	KIF11 →	-0.780	-0.105	.001	.001	3	5
HNSC	DAB2 →	+0.866	+0.118	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006551 vs BUB1B — COAD

Explore this scatter interactively →