L-leucine metabolic process

Across TCGA cell cohorts, RNA activity of the L-leucine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCCC1, ELF3, and PPM1F, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-leucine metabolic process activity versus MCCC1 in OVARY (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MCCC1 →	+0.890	+0.408	.001	.004	3	8
PANCREAS	ELF3 →	+3.548	+0.493	.001	<.001	3	7
PANCREAS	PPM1F →	-1.729	-0.500	<.001	<.001	3	6
PANCREAS	CDC20 →	-1.070	-0.404	.004	<.001	3	6
PANCREAS	FAAH →	+1.804	+0.396	.006	.003	3	6
PANCREAS	TNK1 →	+1.227	+0.590	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006551 vs MCCC1 — OVARY

Explore this scatter interactively →