Isoleucine metabolic process

Across TCGA patient cohorts, RNA activity of the Isoleucine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDS, PARVG, and XRCC5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoleucine metabolic process activity versus SDS in CCRCC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SDS →	+0.735	+0.071	<.001	<.001	3	9
GBM	PARVG →	+0.448	+0.057	.001	.001	3	7
GBM	XRCC5 →	-0.299	-0.093	<.001	<.001	3	7
GBM	IFI30 →	+0.710	+0.071	<.001	.002	3	6
COAD	ATP6V1B2 →	+0.226	+0.059	.004	<.001	3	6
OV	ADA2 →	+0.408	+0.047	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006549 vs SDS — CCRCC

Explore this scatter interactively →