Isoleucine metabolic process

Across TCGA patient cohorts, RNA activity of the Isoleucine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CG, PREX1, and FGD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoleucine metabolic process activity versus PIK3CG in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIK3CG →	+0.709	+0.080	<.001	<.001	3	6
LSCC	PREX1 →	+0.641	+0.091	<.001	<.001	3	6
HNSC	FGD2 →	+0.654	+0.078	<.001	<.001	3	6
HNSC	KLHL6 →	+0.869	+0.112	<.001	<.001	3	6
UCEC	GIMAP7 →	+1.028	+0.143	<.001	<.001	3	6
HNSC	CLECL1 →	+0.728	+0.101	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006549 vs PIK3CG — HNSC

Explore this scatter interactively →