Isoleucine metabolic process

Across TCGA cell cohorts, RNA activity of the Isoleucine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-E, KLHDC9, and ENKD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-E grouped by Isoleucine metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HLA-E →	-1.086	-0.338	<.001	<.001	3	5
URINARY_TRACT	KLHDC9 →	-2.063	-0.338	<.001	<.001	3	4
KIDNEY	ENKD1 →	-1.007	-0.914	.005	.007	3	4
BLOOD_Leukemia	CKAP4 →	-2.685	-0.347	.002	<.001	2	5
BLOOD_Leukemia	OFD1 →	-1.381	-0.332	<.001	.001	3	4
OVARY	PSTK →	+0.829	+1.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-E by Isoleucine metabolic process activity — URINARY_TRACT

Explore this box plot interactively →