Isoleucine metabolic process

Across TCGA cell cohorts, RNA activity of the Isoleucine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCKDK, BCAT2, and VKORC1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoleucine metabolic process activity versus BCKDK in URINARY_TRACT (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BCKDK →	+0.941	+0.134	<.001	<.001	3	13
BREAST	BCAT2 →	+0.977	+0.185	<.001	<.001	3	11
URINARY_TRACT	VKORC1 →	+1.238	+0.164	<.001	<.001	3	9
LUNG_NSCLC_LUSC	ANKRD33B →	+2.261	+0.162	.004	.001	3	7
LUNG_SCLC	TRAP1 →	+1.055	+0.189	.002	<.001	3	7
URINARY_TRACT	UROD →	+0.693	+0.104	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006549 vs BCKDK — URINARY_TRACT

Explore this scatter interactively →