Histidine catabolic process

Across TCGA patient cohorts, RNA activity of the Histidine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLC, LINC02048, and LTB4R2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histidine catabolic process activity versus GCLC in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GCLC →	+1.534	+0.143	<.001	<.001	3	3
PDAC	LINC02048 →	-0.183	-0.033	.009	.002	3	3
HNSC	LTB4R2 →	+0.515	+0.533	<.001	<.001	3	3
LSCC	CNN3 →	-0.664	-0.176	<.001	<.001	3	3
GBM	RMND5A →	+0.279	+0.509	<.001	.004	3	3
GBM	PLEKHH1 →	+0.951	+0.636	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006548 vs GCLC — LSCC

Explore this scatter interactively →