Histidine catabolic process

Across TCGA patient cohorts, RNA activity of the Histidine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARNMT1, SHANK3_S1246, and SSH3_S484, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histidine catabolic process activity versus CARNMT1 in UCEC (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CARNMT1 →	+0.532	+0.143	<.001	<.001	3	3
GBM	SHANK3_S1246 →	+0.819	+0.983	<.001	.001	3	2
BRCA	SSH3_S484 →	+0.773	+0.128	<.001	.005	3	2
BRCA	BACH2_S510 →	-0.684	-0.072	.001	<.001	3	2
BRCA	BIN2_S357 →	-0.597	-0.632	.004	<.001	3	2
BRCA	CRTC2_S70 →	+0.792	+0.144	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006548 vs CARNMT1 — UCEC

Explore this scatter interactively →