Histidine catabolic process

Across TCGA cell cohorts, RNA activity of the Histidine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPLA2, CCHCR1, and ERVMER34-1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNPLA2 grouped by Histidine catabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PNPLA2 →	+0.747	+1.992	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CCHCR1 →	-0.643	-0.780	<.001	.002	3	4
LUNG_NSCLC_LUAD	ERVMER34-1 →	+1.283	+0.956	.008	.005	2	5
KIDNEY	CRH →	+0.073	+1.216	.004	.002	3	4
OVARY	CSPP1 →	+0.777	+1.538	<.001	<.001	3	3
PANCREAS	RANGAP1 →	-0.556	-1.266	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNPLA2 by Histidine catabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →