Glutamate catabolic process

Across TCGA patient cohorts, RNA activity of the Glutamate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR43_S77, CEP55, and EIF3K, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate catabolic process activity versus WDR43_S77 in PDAC (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	WDR43_S77 →	+0.725	+0.063	<.001	.002	3	5
LSCC	CEP55 →	+0.356	+0.062	<.001	<.001	3	5
HNSC	EIF3K →	+0.118	+0.144	.007	<.001	3	5
PDAC	MRPS11 →	+0.259	+0.064	.005	.004	3	5
LSCC	PARK7 →	-0.201	-0.073	<.001	<.001	3	5
PDAC	TBCEL →	-0.339	-0.068	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006538 vs WDR43_S77 — PDAC

Explore this scatter interactively →