Glutamate catabolic process

Across TCGA patient cohorts, RNA activity of the Glutamate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFAM1, NCF4, and RAC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate catabolic process activity versus NFAM1 in BRCA (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NFAM1 →	-0.761	-0.140	<.001	.001	3	5
GBM	NCF4 →	-0.721	-0.166	.001	<.001	3	4
GBM	RAC2 →	-0.555	-0.112	.001	.002	3	4
GBM	IL2RA →	-1.102	-0.148	<.001	<.001	3	4
GBM	PIK3R5 →	-0.635	-0.160	.008	.001	3	4
GBM	DOK3 →	-0.432	-0.134	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006538 vs NFAM1 — BRCA

Explore this scatter interactively →