Glutamate catabolic process

Across TCGA cell cohorts, RNA activity of the Glutamate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DZIP1L, C7orf26, and LDB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DZIP1L grouped by Glutamate catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DZIP1L →	-1.163	-1.128	.009	.004	3	5
KIDNEY	C7orf26 →	-0.901	-1.583	<.001	<.001	3	4
LIVER	LDB1 →	-1.060	-1.572	<.001	.005	3	4
URINARY_TRACT	PLXND1 →	-2.157	-1.474	<.001	.004	3	4
BLOOD_Leukemia	ZNF184 →	+0.671	+0.774	.006	.001	3	4
CNS	TNFAIP2 →	-1.702	-0.976	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DZIP1L by Glutamate catabolic process activity — LIVER

Explore this box plot interactively →