Glutamate catabolic process

Across TCGA cell cohorts, RNA activity of the Glutamate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MERTK, IL2RB, and GALK1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate catabolic process activity versus MERTK in BREAST (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MERTK →	-0.924	-0.249	<.001	.007	3	2
BREAST	IL2RB →	+0.176	+0.249	<.001	.007	3	1
BREAST	GALK1 →	+0.931	+0.249	.001	.007	3	1
BREAST	COPS7A →	+1.088	+0.249	<.001	.007	3	1
BREAST	ANGPTL1 →	+0.156	+0.249	.002	.007	3	1
BREAST	IL1RN →	+1.855	+0.249	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006538 vs MERTK — BREAST

Explore this scatter interactively →