Glutamate catabolic process

Across TCGA cell cohorts, RNA activity of the Glutamate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C7orf50, DNAJC7, and GBF1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate catabolic process activity versus C7orf50 in BREAST (Pearson r = -0.89).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C7orf50 →	-1.370	-0.297	.002	.001	3	2
BREAST	DNAJC7 →	-0.859	-0.296	.002	.002	3	2
SKIN	GBF1 →	+0.751	+0.338	.005	.002	3	1
SKIN	LPXN →	+1.506	+0.380	.006	.004	3	1
SKIN	POLE4 →	-1.236	-0.288	.002	.008	3	1
SKIN	VPS4B →	-0.721	-0.383	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006538 vs C7orf50 — BREAST

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