Aspartate metabolic process

Across TCGA patient cohorts, RNA activity of the Aspartate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSM5, ASPA, and TNNC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate metabolic process activity versus ACSM5 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACSM5 →	+0.734	+0.131	.006	.006	3	6
BRCA	ASPA →	+0.619	+0.200	.002	<.001	3	5
LSCC	TNNC1 →	+1.048	+0.191	<.001	<.001	3	5
LSCC	ZWINT →	-0.681	-0.115	<.001	<.001	3	5
BRCA	F13A1 →	+1.292	+0.138	<.001	.001	3	5
LSCC	F10 →	+0.556	+0.155	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006531 vs ACSM5 — GBM

Explore this scatter interactively →