Aspartate metabolic process

Across TCGA cell cohorts, RNA activity of the Aspartate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTX1, C15orf62, and GAREM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTX1 grouped by Aspartate metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MTX1 →	-0.621	-1.571	.003	<.001	3	4
LIVER	C15orf62 →	-0.720	-1.530	.001	.002	3	4
OESOPHAGUS	GAREM2 →	-1.207	-1.004	.001	.003	3	3
PANCREAS	PYCARD →	+2.612	+1.379	.008	.001	2	4
CNS	VWA7 →	-0.382	-0.791	.006	.005	2	4
LIVER	RPAP1 →	-1.160	-1.939	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTX1 by Aspartate metabolic process activity — LIVER

Explore this box plot interactively →