Aspartate metabolic process

Across TCGA cell cohorts, RNA activity of the Aspartate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD1L, SLC43A1, and NAMPT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aspartate metabolic process activity versus GPD1L in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GPD1L →	+1.240	+0.292	<.001	<.001	3	5
SKIN	SLC43A1 →	+1.475	+0.245	.001	.005	3	5
PANCREAS	NAMPT →	+1.235	+0.246	.007	.004	3	5
LARGE_INTESTINE	ASS1 →	+2.262	+0.212	.002	.003	3	5
LARGE_INTESTINE	PIP5K1B →	+2.459	+0.229	<.001	.002	3	5
LARGE_INTESTINE	MYB →	+1.464	+0.184	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006531 vs GPD1L — LUNG_SCLC

Explore this scatter interactively →