Asparagine metabolic process

Across TCGA patient cohorts, RNA activity of the Asparagine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, DLGAP5, and MTHFD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asparagine metabolic process activity versus TTK in UCEC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TTK →	+1.013	+0.095	<.001	.001	3	5
UCEC	DLGAP5 →	+0.963	+0.083	.003	.005	3	5
UCEC	MTHFD2 →	+0.604	+0.091	<.001	.001	2	6
COAD	ASRGL1 →	+1.100	+0.110	<.001	<.001	3	5
COAD	CARMN →	-0.815	-0.090	.001	.009	3	5
HNSC	NEDD4 →	-0.546	-0.088	.007	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006528 vs TTK — UCEC

Explore this scatter interactively →