Asparagine metabolic process

Across TCGA cell cohorts, RNA activity of the Asparagine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX1, ATP5F1D, and ZNF215, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asparagine metabolic process activity versus PBX1 in BLOOD_Myeloma (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PBX1 →	-3.352	-0.169	<.001	.005	3	5
STOMACH	ATP5F1D →	+0.938	+0.279	<.001	.008	3	5
LUNG_NSCLC_LUSC	ZNF215 →	+1.897	+0.206	<.001	<.001	3	4
LUNG_SCLC	EMX1 →	+1.811	+0.183	.001	.006	3	4
STOMACH	PHLDB2 →	-3.775	-0.324	<.001	.002	3	4
LUNG_NSCLC_LUSC	STT3B →	-0.755	-0.194	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006528 vs PBX1 — BLOOD_Myeloma

Explore this scatter interactively →