Arginine catabolic process

Across TCGA patient cohorts, RNA activity of the Arginine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDAH1, TOM1L1, and CMBL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine catabolic process activity versus DDAH1 in OV (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDAH1 →	+0.650	+0.059	<.001	.002	3	6
HNSC	TOM1L1 →	+0.396	+0.055	<.001	.002	3	5
BRCA	CMBL →	+0.969	+0.099	<.001	<.001	3	5
BRCA	AHCYL1 →	+0.321	+0.059	<.001	<.001	3	5
OV	BICD2_S823 →	-0.862	-0.055	.006	.008	3	5
BRCA	CLUAP1_S409 →	+0.564	+0.075	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006527 vs DDAH1 — OV

Explore this scatter interactively →