Arginine catabolic process

Across TCGA patient cohorts, RNA activity of the Arginine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMOX1, CXCL8, and FCGR3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine catabolic process activity versus HMOX1 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HMOX1 →	+1.099	+0.158	<.001	.001	3	5
PDAC	CXCL8 →	+1.073	+0.277	<.001	<.001	3	5
LSCC	FCGR3B →	+0.757	+0.119	.005	.001	3	5
UCEC	AQP9 →	+0.898	+0.234	.009	.001	3	4
UCEC	PARK7P1 →	-0.567	-0.330	<.001	.001	3	4
UCEC	LINC01145 →	-0.431	-0.306	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006527 vs HMOX1 — GBM

Explore this scatter interactively →