Arginine catabolic process

Across TCGA patient cohorts, RNA activity of the Arginine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRNP40, SNRPA1, and DIDO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine catabolic process activity versus SNRNP40 in GBM (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRNP40 →	-0.253	-0.243	<.001	<.001	3	5
GBM	SNRPA1 →	-0.235	-0.192	<.001	<.001	3	5
GBM	DIDO1 →	-0.204	-0.178	<.001	<.001	3	5
GBM	IK →	-0.251	-0.199	<.001	<.001	3	5
GBM	PRPF3 →	-0.277	-0.242	<.001	<.001	3	5
OV	KMT2D_S1180 →	-0.755	-0.128	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006527 vs SNRNP40 — GBM

Explore this scatter interactively →