Arginine catabolic process

Across TCGA cell cohorts, RNA activity of the Arginine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMTOR2, IL13RA1, and AGR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMTOR2 grouped by Arginine catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LAMTOR2 →	+0.617	+1.152	.008	.003	3	5
SOFT_TISSUE	IL13RA1 →	+1.948	+1.344	.001	<.001	3	4
BLOOD_Lymphoma	AGR3 →	-0.173	-1.967	<.001	<.001	3	4
KIDNEY	CUL1 →	+0.734	+1.119	.001	.005	3	4
BREAST	ABCF1 →	+0.771	+0.807	.008	.004	3	4
SOFT_TISSUE	MREG →	-1.306	-1.985	.002	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMTOR2 by Arginine catabolic process activity — OESOPHAGUS

Explore this box plot interactively →