Arginine catabolic process

Across TCGA cell cohorts, RNA activity of the Arginine catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHO, TRH, and VCPIP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHO grouped by Arginine catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RHO →	+0.386	+0.391	.004	.001	3	2
OVARY	TRH →	-0.413	-0.427	.004	.001	3	1
OVARY	VCPIP1 →	+0.350	+0.378	.008	.006	3	1
OVARY	PDIK1L →	+0.201	+0.308	.002	.004	3	1
OVARY	RPS6KB2 →	+0.310	+0.308	.002	.004	3	1
OVARY	ZNF491 →	+0.217	+0.308	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHO by Arginine catabolic process activity — OVARY

Explore this box plot interactively →