Arginine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Arginine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERO1A, PIP5K1C, and TOP2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine biosynthetic process activity versus ERO1A in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERO1A →	+0.561	+0.094	<.001	<.001	3	6
BRCA	PIP5K1C →	-0.221	-0.055	<.001	.001	3	5
HNSC	TOP2B →	-0.283	-0.083	.002	.002	3	5
CCRCC	AJUBA_S119 →	+0.419	+0.098	.003	.001	3	5
PDAC	EPB41L2 →	-0.405	-0.076	<.001	.003	3	5
HNSC	FAM83H →	+0.506	+0.069	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006526 vs ERO1A — GBM

Explore this scatter interactively →