Arginine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Arginine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRA1, GAPT, and FUCA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine biosynthetic process activity versus LILRA1 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LILRA1 →	+0.463	+0.099	<.001	.001	3	5
LSCC	GAPT →	+1.031	+0.117	<.001	<.001	3	5
LSCC	FUCA1 →	+0.763	+0.115	<.001	<.001	3	5
UCEC	SLC4A4 →	+1.237	+0.140	.004	.003	3	5
UCEC	SOD2 →	+0.724	+0.165	.008	<.001	3	4
LSCC	UNG →	-0.713	-0.099	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006526 vs LILRA1 — LSCC

Explore this scatter interactively →