Arginine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Arginine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF461, HEY1, and ZFYVE19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF461 grouped by Arginine biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF461 →	-2.030	-2.322	.005	<.001	3	4
BONE	HEY1 →	-1.495	-1.433	.004	<.001	3	4
PANCREAS	ZFYVE19 →	-0.861	-1.243	.001	.007	3	4
OESOPHAGUS	DNMT3B →	-1.029	-1.274	<.001	<.001	3	4
LARGE_INTESTINE	PPP5D1 →	-0.277	-1.252	.005	.009	3	4
BREAST	PDLIM7 →	-1.179	-0.862	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF461 by Arginine biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →