Arginine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Arginine biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, CARS1, and WNT6, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM97 grouped by Arginine biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM97 →	-0.216	-0.194	.001	.007	3	1
LARGE_INTESTINE	CARS1 →	-0.570	-0.194	.008	.007	3	1
LARGE_INTESTINE	WNT6 →	+0.260	+0.194	<.001	.007	3	1
LARGE_INTESTINE	SFPQ →	+0.479	+0.194	.003	.007	3	1
LARGE_INTESTINE	TIMM10 →	-0.223	-0.194	.001	.007	3	1
LARGE_INTESTINE	TMEM117 →	-0.243	-0.194	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM97 by Arginine biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →