Arginine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Arginine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS13, PRRX2, and SULT1A1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine biosynthetic process activity versus RPS13 in LARGE_INTESTINE (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPS13 →	+0.974	+0.269	.006	.001	3	1
LARGE_INTESTINE	PRRX2 →	-0.200	-0.269	.002	.001	3	1
LARGE_INTESTINE	SULT1A1 →	-1.450	-0.210	.005	.001	3	1
LARGE_INTESTINE	MEX3A →	+1.460	+0.245	.007	.006	3	1
LARGE_INTESTINE	MIOX →	-0.405	-0.269	.009	.001	2	1
LARGE_INTESTINE	TRIM16L →	+1.895	+0.223	.005	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006526 vs RPS13 — LARGE_INTESTINE

Explore this scatter interactively →