Arginine metabolic process

Across TCGA patient cohorts, RNA activity of the Arginine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR3B, CXCR1, and FPR2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine metabolic process activity versus FCGR3B in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FCGR3B →	+1.157	+0.244	<.001	<.001	2	7
LSCC	CXCR1 →	+1.359	+0.210	<.001	<.001	3	6
PDAC	FPR2 →	+0.861	+0.184	.003	.004	3	6
UCEC	CXCR2 →	+0.744	+0.235	.001	<.001	3	6
LSCC	FCAR →	+0.784	+0.194	<.001	<.001	3	6
LSCC	MEFV →	+0.870	+0.169	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006525 vs FCGR3B — HNSC

Explore this scatter interactively →