Arginine metabolic process

Across TCGA cell cohorts, RNA activity of the Arginine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCRIP2, ANXA2R, and GMDS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine metabolic process activity versus MCRIP2 in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MCRIP2 →	+1.050	+0.455	.001	<.001	3	5
STOMACH	ANXA2R →	-1.686	-0.479	<.001	.001	3	5
BLOOD_Myeloma	GMDS →	+1.133	+0.309	.002	.002	2	6
OVARY	OAT →	+0.728	+0.272	.007	<.001	3	5
BLOOD_Myeloma	ASS1 →	+3.694	+0.344	.001	<.001	3	5
LARGE_INTESTINE	PLEKHO2 →	-0.870	-0.382	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006525 vs MCRIP2 — STOMACH

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