Amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC8, TTPAL, and SHTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZCCHC8 grouped by Amino acid metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZCCHC8 →	+0.607	+0.157	.005	.007	3	5
BONE	TTPAL →	-0.895	-0.175	.009	.002	3	4
LUNG_NSCLC_LUAD	SHTN1 →	+0.666	+0.116	.005	.001	3	4
LUNG_SCLC	AREL1 →	-0.491	-0.132	.004	.006	3	4
LIVER	KMT5A →	+0.880	+0.185	.001	.001	3	4
LUNG_NSCLC_LUSC	CUX1 →	+1.219	+0.162	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZCCHC8 by Amino acid metabolic process activity — STOMACH

Explore this box plot interactively →