Amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM8, MAN2A2, and ACADSB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid metabolic process activity versus CMTM8 in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CMTM8 →	+1.841	+0.350	.009	.005	3	9
URINARY_TRACT	MAN2A2 →	+1.098	+0.417	.002	.003	3	7
URINARY_TRACT	ACADSB →	+1.656	+0.348	<.001	<.001	3	7
STOMACH	DSE →	-3.061	-0.302	<.001	.006	3	6
STOMACH	PYCR1 →	+1.252	+0.324	<.001	.001	3	6
STOMACH	ARL14EPL →	-0.567	-0.229	.008	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006520 vs CMTM8 — STOMACH

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