Glycoprotein catabolic process

Across TCGA patient cohorts, RNA activity of the Glycoprotein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA2, HCK, and LCP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoprotein catabolic process activity versus ADA2 in CCRCC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ADA2 →	+0.453	+0.027	<.001	.003	3	8
GBM	HCK →	+0.507	+0.058	<.001	<.001	3	8
GBM	LCP1 →	+0.928	+0.072	<.001	<.001	3	8
GBM	MYO1G →	+0.674	+0.067	<.001	<.001	3	8
GBM	FERMT3 →	+0.463	+0.044	<.001	<.001	3	8
GBM	TNFAIP8L2 →	+0.756	+0.065	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006516 vs ADA2 — CCRCC

Explore this scatter interactively →