Glycoprotein catabolic process

Across TCGA patient cohorts, RNA activity of the Glycoprotein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKV1OR2-108, CD14, and DMAC2L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoprotein catabolic process activity versus IGKV1OR2-108 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGKV1OR2-108 →	+1.228	+0.189	<.001	.001	3	6
GBM	CD14 →	+1.274	+0.261	<.001	<.001	3	6
GBM	DMAC2L →	-0.384	-0.175	<.001	.001	3	5
GBM	STAB1 →	+1.149	+0.240	<.001	<.001	3	5
GBM	COL8A1 →	+1.501	+0.175	<.001	<.001	3	5
GBM	DAB2 →	+0.623	+0.161	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006516 vs IGKV1OR2-108 — LSCC

Explore this scatter interactively →