Glycoprotein catabolic process

Across TCGA cell cohorts, RNA activity of the Glycoprotein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF385C, VASP, and GGACT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF385C grouped by Glycoprotein catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF385C →	+1.051	+0.920	.001	.002	3	4
CNS	VASP →	-1.327	-1.042	.001	.001	3	4
BLOOD_Leukemia	GGACT →	-1.545	-0.903	.001	.004	3	4
PANCREAS	RACGAP1 →	+0.897	+1.064	.007	.007	2	4
PANCREAS	PLEKHF1 →	-1.112	-1.322	.008	.001	3	3
PANCREAS	RAB44 →	-0.031	-0.992	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF385C by Glycoprotein catabolic process activity — STOMACH

Explore this box plot interactively →