Glycoprotein catabolic process

Across TCGA cell cohorts, RNA activity of the Glycoprotein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSA, HEXA, and TMBIM6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoprotein catabolic process activity versus CTSA in LUNG_SCLC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CTSA →	+1.031	+1.155	<.001	<.001	3	5
PANCREAS	HEXA →	+0.710	+1.273	.007	<.001	3	5
BLOOD_Lymphoma	TMBIM6 →	+1.213	+1.216	.001	.001	3	5
BLOOD_Lymphoma	BTD →	+1.232	+1.273	.003	.002	3	5
LUNG_SCLC	ATP6V1G2 →	-1.528	-0.960	<.001	<.001	3	5
LUNG_SCLC	PLOD1 →	+1.436	+1.082	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006516 vs CTSA — LUNG_SCLC

Explore this scatter interactively →