Protein monoubiquitination

Across TCGA cell cohorts, RNA activity of the Protein monoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF165, DUSP16, and RAB4B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF165 grouped by Protein monoubiquitination-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNF165 →	+1.412	+0.196	.002	.006	3	4
LARGE_INTESTINE	DUSP16 →	+1.034	+0.162	<.001	.001	3	4
LUNG_SCLC	RAB4B →	+1.007	+0.198	<.001	.001	3	4
BREAST	SEMA4A →	+2.349	+0.292	<.001	.002	3	4
BLOOD_Lymphoma	NPIPB11 →	+1.061	+0.220	.005	.007	3	4
BLOOD_Lymphoma	OGFR →	+0.806	+0.220	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF165 by Protein monoubiquitination activity — BONE

Explore this box plot interactively →