Protein monoubiquitination

Across TCGA cell cohorts, RNA activity of the Protein monoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPRL3, EEF2, and RNF126, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein monoubiquitination activity versus NPRL3 in OVARY (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NPRL3 →	+1.132	+1.657	<.001	<.001	3	6
OVARY	EEF2 →	+0.955	+1.383	<.001	<.001	3	6
BLOOD_Lymphoma	RNF126 →	+0.791	+0.232	<.001	<.001	3	6
BONE	B4GALT1 →	-2.354	-1.998	.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	MED28 →	+1.162	+1.980	<.001	<.001	3	6
BONE	SRSF7 →	+0.833	+1.925	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006513 vs NPRL3 — OVARY

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