GPI anchor metabolic process

Across TCGA patient cohorts, RNA activity of the GPI anchor metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R9A_S840, RPL5, and SEC24A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GPI anchor metabolic process activity versus PPP1R9A_S840 in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R9A_S840 →	+0.671	+0.040	<.001	<.001	3	6
BRCA	RPL5 →	-0.222	-0.026	<.001	<.001	3	6
CCRCC	SEC24A →	-0.305	-0.037	<.001	<.001	3	6
BRCA	CALR →	-0.353	-0.038	<.001	<.001	3	6
BRCA	CEBPB →	-0.386	-0.024	<.001	<.001	3	6
HNSC	NRBF2 →	-0.406	-0.064	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006505 vs PPP1R9A_S840 — GBM

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