GPI anchor metabolic process

Across TCGA cell cohorts, RNA activity of the GPI anchor metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H12A, RPN2, and PRKCD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GPI anchor metabolic process activity versus ZC3H12A in LUNG_SCLC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZC3H12A →	+1.098	+1.210	.004	.001	3	6
LUNG_NSCLC_LUAD	RPN2 →	+0.657	+1.028	.006	.005	3	5
BLOOD_Leukemia	PRKCD →	+1.432	+0.518	.002	.003	3	5
LIVER	OLFML2A →	+3.600	+1.897	<.001	.002	3	5
STOMACH	CHCHD10 →	-1.312	-1.028	.001	.008	3	5
LIVER	MRPL42 →	-0.950	-1.788	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006505 vs ZC3H12A — LUNG_SCLC

Explore this scatter interactively →