N-terminal protein lipidation

Across TCGA patient cohorts, RNA activity of the N-terminal protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYPN, CTNNA3, and GOLGA6L6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-terminal protein lipidation activity versus MYPN in HNSC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYPN →	+1.563	+0.160	<.001	<.001	3	3
HNSC	CTNNA3 →	+0.535	+0.109	<.001	<.001	3	3
OV	GOLGA6L6 →	+0.014	+0.192	<.001	.001	3	3
COAD	AZU1 →	+0.099	+0.139	.004	<.001	3	2
COAD	GPR150 →	+0.296	+0.149	.002	.007	3	2
COAD	TRMT112P6 →	-0.422	-0.164	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006498 vs MYPN — HNSC

Explore this scatter interactively →