N-terminal protein lipidation

Across TCGA cell cohorts, RNA activity of the N-terminal protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGTPBP1, TCEAL3, and IGFBPL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGTPBP1 grouped by N-terminal protein lipidation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AGTPBP1 →	-1.113	-1.541	<.001	.004	3	4
LUNG_NSCLC_LUSC	TCEAL3 →	-2.526	-1.879	.008	<.001	3	4
OVARY	IGFBPL1 →	-0.770	-0.776	.006	.005	3	3
BLOOD_Leukemia	DPM2 →	+0.553	+1.463	<.001	<.001	3	3
LUNG_NSCLC_LUSC	ARMC8 →	-0.750	-1.635	.001	<.001	3	3
LUNG_SCLC	TTF2 →	-0.846	-1.078	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGTPBP1 by N-terminal protein lipidation activity — LUNG_SCLC

Explore this box plot interactively →