Protein O-linked glycosylation

Across TCGA patient cohorts, RNA activity of the Protein O-linked glycosylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, LOX, and MAP1A_S2022, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein O-linked glycosylation activity versus FSTL1 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FSTL1 →	+0.628	+0.039	<.001	<.001	3	6
BRCA	LOX →	+0.526	+0.022	<.001	<.001	3	6
LSCC	MAP1A_S2022 →	+0.633	+0.026	.001	.002	3	5
LSCC	RCN3 →	+0.440	+0.030	<.001	.002	3	5
BRCA	SERPINF1 →	+0.536	+0.018	<.001	<.001	3	5
CCRCC	SPON2 →	+1.531	+0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006493 vs FSTL1 — LSCC

Explore this scatter interactively →