Protein O-linked glycosylation

Across TCGA patient cohorts, RNA activity of the Protein O-linked glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG7, MANSC1, and TRAJ53, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein O-linked glycosylation activity versus SNHG7 in OV (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNHG7 →	-0.581	-0.148	.004	.008	3	4
OV	MANSC1 →	+0.851	+0.233	.003	.003	3	4
PDAC	TRAJ53 →	-0.808	-0.194	<.001	<.001	3	4
HNSC	SLC2A4 →	-0.864	-0.204	<.001	<.001	3	3
HNSC	ZACN →	-0.442	-0.158	.002	.002	3	3
HNSC	MBP →	-0.404	-0.140	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006493 vs SNHG7 — OV

Explore this scatter interactively →