N-glycan processing

Across TCGA patient cohorts, RNA activity of the N-glycan processing pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS13C, DMXL1, and MGAT4A, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-glycan processing activity versus VPS13C in DLBC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	VPS13C →	+1.661	+0.082	<.001	<.001	3	33
UVM	DMXL1 →	+1.538	+0.045	<.001	<.001	3	33
ESCA	MGAT4A →	+2.052	+0.110	<.001	<.001	3	32
DLBC	MAN2A1 →	+1.188	+0.070	<.001	<.001	3	31
DLBC	PIKFYVE →	+1.602	+0.091	<.001	<.001	3	31
DLBC	APAF1 →	+1.857	+0.088	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006491 vs VPS13C — DLBC

Explore this scatter interactively →