N-glycan processing

Across TCGA patient cohorts, RNA activity of the N-glycan processing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, CORO1A, and ARHGAP25, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-glycan processing activity versus WAS in GBM (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.494	+0.051	<.001	<.001	3	8
LSCC	CORO1A →	+0.510	+0.090	<.001	<.001	3	8
HNSC	ARHGAP25 →	+0.796	+0.121	<.001	<.001	3	8
COAD	ARHGAP9 →	+0.479	+0.031	.001	.002	3	8
HNSC	EVL →	+0.791	+0.106	<.001	<.001	3	8
LSCC	ANKRD44 →	+0.414	+0.097	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006491 vs WAS — GBM

Explore this scatter interactively →